氢分子与健康
基础知识
慢性病防治
美容抗衰老
科研文献

氢气对全脑缺血的保护作用.pdf

作者:admin  来源:未知  更新时间:2017-06-29 16:57:00

http://www.sciencedirect.com/science/article/pii/S0022480414005290

Hydrogen-rich saline attenuates neuronal ischemia reperfusion injury by protecti.pdf


氢气对全脑缺血再灌注损伤保护作用的研究,是氢气领域神经系统损伤保护方面研究最多的,其中发表论文数量最多的是南京军区总医院麻醉科段满林教授实验室,主要开展用氢气生理盐水注射保护四动脉结扎全脑缺血再灌注损伤。

最近,该课题组再次发表一篇论文,从线粒体损伤角度,证明氢气对脑缺血的保护效应,主要从线粒体电位、线粒体通透性转换孔开放、细胞色素C、电子显微镜和光学显微镜观察等研究方法,并采用脑室内注射苍术苷(线粒体通道抑制剂?)。研究结果发现,氢气生理盐水能有效保护全脑缺血引起的脑组织损伤和线粒体的病变,说明保护线粒体损伤可能是氢气保护全脑缺血的原因。

该论文发表在JSR上。

相关文献

1.       Ohsawa, Ikuroh, et al. "Hydrogenacts as a therapeutic antioxidant by selectively reducing cytotoxic oxygenradicals." Nature medicine 13.6 (2007): 688-694.

2.       Cai, Jianmei, et al."Neuroprotective effects of hydrogen saline in neonatal hypoxia–ischemiarat model." Brain research 1256 (2009): 129-137.

3.       Sun, Qiang, et al. "Hydrogen-richsaline protects myocardium against ischemia/reperfusion injury in rats." ExperimentalBiology and Medicine 234.10 (2009): 1212-1219.

4.       Ji, Qing, et al. "The effect ofhydrogen-rich saline on the brain of rats with transient ischemia." Journalof Surgical Research168.1 (2011): e95-e101.

5.       Sun, Qiang, et al. "Hydrogen-richsaline protects myocardium against ischemia/reperfusion injury in rats." ExperimentalBiology and Medicine 234.10 (2009): 1212-1219.

6.       Zheng, Xingfeng, et al."Hydrogen-rich saline protects against intestinal ischemia/reperfusioninjury in rats." Free radical research 43.5 (2009): 478-484.

7.       Liu, Ying, et al. "Hydrogen salineoffers neuroprotection by reducing oxidative stress in a focal cerebralischemia-reperfusion rat model." Med Gas Res 1.1 (2011): 15.

8.       Chen, Han, et al. "The effects ofhydrogen-rich saline on the contractile and structural changes of intestineinduced by ischemia-reperfusion in rats." Journal of Surgical Research167.2 (2011): 316-322.

9.       Cai, Jianmei, et al. "Hydrogentherapy reduces apoptosis in neonatal hypoxia–ischemia rat model." Neuroscienceletters 441.2 (2008): 167-172.

10.      Li,Jianjun, et al. "Protective effects of hydrogen-rich saline in a rat modelof permanent focal cerebral ischemia via reducing oxidative stress andinflammatory cytokines." Brain research 1486 (2012): 103-111.

11.      Huang,Yi, et al. "Beneficial effects of hydrogen gas against spinal cordischemia–reperfusion injury in rabbits." Brain research1378(2011): 125-136.

12.      Wang,Fei, et al. "Hydrogen-rich saline protects against renalischemia/reperfusion injury in rats." Journal of Surgical Research167.2 (2011): e339-e344.

13.      Nagatani,Kimihiro, et al. "Effect of hydrogen gas on the survival rate of micefollowing global cerebral ischemia." Shock 37.6 (2012): 645-652.

14.      Hong,Y., S. Chen, and J. M. Zhang. "Hydrogen as a selective antioxidant: areview of clinical and experimental studies."Journal of InternationalMedical Research 38.6 (2010): 1893-1903.

15.      Hayashida,Kentaro, et al. "Inhalation of hydrogen gas reduces infarct size in therat model of myocardial ischemia–reperfusion injury." Biochemical andbiophysical research communications 373.1 (2008): 30-35.

16.      Sun,Quiang, et al. "Hydrogen-rich saline reduces delayed neurologic sequelaein experimental carbon monoxide toxicity."Critical care medicine39.4 (2011): 765-769.

17.      Matchett,Gerald A., et al. "Hydrogen gas is ineffective in moderate and severeneonatal hypoxia–ischemia rat models." Brain research 1259 (2009):90-97.

18.      Hugyecz,Marietta, et al. "Hydrogen supplemented air inhalation reduces changes ofprooxidant enzyme and gap junction protein levels after transient globalcerebral ischemia in the rat hippocampus." Brain research 1404(2011): 31-38.

19.      Shen,Li, et al. "Hydrogen-rich saline is cerebroprotective in a rat model ofdeep hypothermic circulatory arrest." Neurochemical research 36.8(2011): 1501-1511.

20.      Zhang,Yufeng, et al. "Anti-inflammatory effect of hydrogen-rich saline in a ratmodel of regional myocardial ischemia and reperfusion." Internationaljournal of cardiology 148.1 (2011): 91-95.

21.      Zhuang,Zong, et al. "Hydrogen-rich saline alleviates early brain injury viareducing oxidative stress and brain edema following experimental subarachnoidhemorrhage in rabbits." BMC neuroscience 13.1 (2012): 47.




本文引用地址:http://blog.sciencenet.cn/blog-41174-799294.html 
狼人干综合影院福利在线观看_亚洲综合视频资源_狼人干综合伊人网最新地址